The Beautiful Mountain Town of Sapa Vietnam

Sapa is one of the naturally serene and lush towns in Vietnam. It attracts many travelers with its magnificent landscape, which features colorful tribal villages, French colonial villages, lush vegetation and numerous green fields stacked on one after another.

Sapa is also close to Fansipan, the highest peak in Vietnam. Nestled at an elevation of 4921 feet or 1500 meters, Sapa is in Hoang Lien Son mountain range, in the northwest region of the country. Because of its geographical location, the town's rugged scenery usually experiences being clouded by a warm mist, which only adds to Sapa's beauty and charm, and making it truly a unique place to visit.

Sapa is about 376 kilometers from capital city of Hanoi. Sapa has risen to be the most popular mountainous district in Vietnam. You will easily be charmed by the terraced rice fields, the ethnic lifestyle and the cool climate, inviting you to stay longer in Sapa than you intended. Becoming a tourist destination paved the way for the establishment of hotels and accommodation facilities in this town so you do not have to worry about finding a place to sleep during those tranquil nights. If you really want to immerse yourself into the Sapa lifestyle, you can also arrange for a homestay in one of the tribal villages.

One of the best things to do in Sapa is walk around the town early in the morning as the tourist crow is not yet in full swing. The town is small, so you can easily navigate your way on foot. In fact, everything in and around town can be explored on foot making the most popular activity in Sapa – trekking. Trekking to various villages is fun and adventurous. Just make sure that you have good trekking shoes or boots and waterproof bag. There are also tours that involve renting a bike or motorbike to explore the countryside and visit waterfalls.

There are other less rigid things to do while in Sapa. You can always visit other neighboring villages like the Lao Chai Village, by hiring local transport like a jeep or van. You may also watch ethnic minor dance performances, sign up for the Hmong sewing classis and visit noticeable attractions like the Han Rong Resort, Sapa Culture Museum, the Sapa Lake, Bac Ha weekend market and the European orchid gardens and colonial buildings.

Sapa is home to a couple of ethnic minorities such as the Dazao and Hmong. These people live a simple life and have managed to maintain their culture and traditions. It is a rewarding travel experience to visit their villages and learn about their way of life. You can ask them to be your trekking guide instead of getting one through the hotel. Other than agriculture, the tribes are also now relying on tourism for a living.

Remember to always be respectful and courteous when dealing with them, especially when taking photos; always ask their permission first. The best time to visit the town is arguably from September to October as this is the period when the rice fields are turning their color from green to yellow. During wintertime, the town receives more of that appealing fog. No matter when you visit Sapa , you will definitely enjoy this new pin on your travel map!

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.

Crush Ringtone

The Crush Ringtone by David Archuleta has quickly become one of the most popular ringtones in the world. It has peaked at # 1 on several popular mobile charts and is currently # 2 on the US iTunes Top Songs Chart. Based on its popularity, the ringtone might soon become one of the most popular mobile phone ringtones ever released!

Crush is the debut single by David Archuleta, American Idol seventh season runner-up. The track was written by Jess Cates, Dave Hodges, and Emanuel Kiriakou. A digital download of the song became available on August 12, 2008. After just one day of airplay, Crush was able to debut at # 93 on the Billboard Pop 100 and # 57 on Pop 100 Airplay. The song is also currently one of the most tracks at Mainstream CHR radio stations.Following the song's digital release onto the US iTunes store on August 12, 2008, the song rose to the # 1 spot on iTunes in less than 24 hours. Crush debuted on the Canadian iTunes store at # 2 and is expected to debut on the Billboard Hot 100 next week.

The popularity of the song has helped make it such a popular phone ringtone. The track has also topped Canadian and Australian music charts, making the ringtone very popular in those nations as well as in the United States.

There is no doubt that David Archuleta's incredible new hit single will end up being one of the most popular ringtones of 2008. If you're looking for a hot new ringtone for your mobile phone – the Crush Ringtone is an awesome choice!

Six Types of Training and Development Techniques

1.On-the-job Training and Lectures

The two most frequently used kinds of training are on-the-job training and lectures, although little research exists as to the effectiveness of either. It is usually impossible to teach someone everything she needs to know at a location away from the workplace. Thus on-the-job training often supplements other kinds of training, e.g., classroom or off-site training; but on-the-job training is frequently the only form of training. It is usually informal, which means, unfortunately, that the trainer does not concentrate on the training as much as she should, and the trainer may not have a well-articulated picture of what the novice needs to learn.

On-the-job training is not successful when used to avoid developing a training program, though it can be an effective part of a well-coordinated training program.

Lectures are used because of their low cost and their capacity to reach many people. Lectures, which use one-way communication as opposed to interactive learning techniques, are much criticized as a training device.

2. Programmed Instruction (PI)

These devices systematically present information to the learner and elicit a response; they use reinforcement principles to promote appropriate responses. When PI was originally developed in the 1950s, it was thought to be useful only for basic subjects. Today the method is used for skills as diverse as air traffic control, blueprint reading, and the analysis of tax returns.

3. Computer-Assisted Instruction (CAI)

With CAI, students can learn at their own pace, as with PI. Because the student interacts with the computer, it is believed by many to be a more dynamic learning device. Educational alternatives can be quickly selected to suit the student’s capabilities, and performance can be monitored continuously. As instruction proceeds, data are gathered for monitoring and improving performance.

4. Audiovisual Techniques

Both television and film extend the range of skills that can be taught and the way information may be presented. Many systems have electronic blackboards and slide projection equipment. The use of techniques that combine audiovisual systems such as closed circuit television and telephones has spawned a new term for this type of training, teletraining. The feature on ” Sesame Street ” illustrates the design and evaluation of one of television’s favorite children’s program as a training device.

5. Simulations

Training simulations replicate the essential characteristics of the real world that are necessary to produce both learning and the transfer of new knowledge and skills to application settings. Both machine and other forms of simulators exist. Machine simulators often have substantial degrees of. physical fidelity; that is, they represent the real world’s operational equipment. The main purpose of simulation, however, is to produce psychological fidelity, that is, to reproduce in the training those processes that will be required on the job. We simulate for a number of reasons, including to control the training environment, for safety, to introduce feedback and other learning principles, and to reduce cost.

6. Business games

They are the direct progeny of war games that have been used to train officers in combat techniques for hundreds of years. Almost all early business games were designed to teach basic business skills, but more recent games also include interpersonal skills. Monopoly might be considered the quintessential business game for young capitalists. It is probably the first place youngsters learned the words mortgage, taxes, and go to jail.